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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

但是他告诉华盛顿报的记者他依然很希望能够读到这封信,毕竟这封信是当时的纯真、关切和真诚的见证。
Cliff Stevenson, an anti-dumping expert who publishes the report based on data filed with the WTO, said the surge in US cases was driven largely by the steel industry. The increase also represented the range of countries from China to Australia, the UK and the Netherlands against which US companies were willing to file anti-dumping complaints.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 居然之家发力“大家居”
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

泡沫气球是泡泡和气球的混合体。
survey

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

?在纽约的交通基础设施遭受巨大的打击。许多城市的地铁隧道被淹没。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The Geneva-based organization issued figures Tuesday showing 1,005,504 migrants from Africa and the Middle East have crossed into the continent by a combination of irregular land and sea routes, a four-fold increase from 2014.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

时间:2009-10-22 编辑:vicki
《一记耳光》(The Slap),NBC,2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人,这部剧改编自一部澳大利亚迷你剧,讲述一个后院生日派对失控后带来的后果。演员阵容非常强大,包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治(Melissa George,她也在原剧中出演角色)。
谎言3:是的,这挺有道理的。说谎原因:方案二会让我显得毫无头绪。
源于:metal(n 金属),因为奖牌是金属做的

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Apple will this week test its customers’ loyalty, buying power and enthusiasm for innovation when it unveils the first iPhone to cost as much as $1,000.
Rich blessings for health and longevity is my special wish for you in the coming year.
“Insead enormously boosted our intercultural experience,” said one alumni survey respondent from Switzerland. “It is a place to learn global culture better than anywhere else.”
People on both sides of the Taiwan Strait are brothers and sisters, and no matter how the situation on the island evolves, the mainland is determined to maintain Cross-Strait stability.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

speculative

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

I'm amazed that Durant didn't get broken in half back in high school, weighing in at 6'9'', 185 lbs. Lucky for Durant, he doesn't make his money banging against big forwards. He relies on his nasty quick-shot jumper.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Maybe 'Melo's mini-fro is the missing key to an NBA Championship for the New York Knicks. Oh no, wait, the missing link is Jeremy Lin—but still, 'Melo's mini-fro wouldn't hurt the Knicks' title hopes.
Most of those surveyed for the report mentioned that positive impacts of social media include socializing with acquaintances and taking in more information.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

但是,小牛队的确应该摆烂。同样的还有国王队,还有热火队,还有魔术队。这些都是中游的球队,即使在最乐观的预测中都没有很高的排名。
10. Are YOU Re-Energized?

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

congratulate
The Explore experience in Brazil is available on both iPhone and Android. Simply open Google Maps on your mobile phone and tap "explore food And drinks near you" at the bottom of the screen. Depending on where you are and time of day, Google Maps will share lists of food and drink locations around you, ranging from "best breakfasts" to "waterside dining", says Bryan Cheng, Product Manager, Google Maps.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

梅瑟威对战麦克格雷戈的战斗
From Yahoo’s bombshell announcement of a data breach that affected millions, to the recent WannaCry and BadRabbit ransomware attacks, 2017 has brought several major cybersecurity disasters.
10.I thought I already sent that email out. I’m sure I did. – Because telling you that it was a low priority and I forgot would probably hurt our relationship。
“我跟她很像,我们真的就像一对老夫妇。”

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Change is also under way at Bain & Company, which announced in November that Manny Maceda will become its global leader in March, the first of Asian heritage, and taking the reins of the Boston-based consultancy from Bob Bechek. Experts say Mr Maceda could be instrumental in helping the firm carve out new areas of expertise and edge away from its reputation as a generalist provider.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Dershowitz said this guidance was too vague to provide students with any real understanding of the school's expectations. "When you punish a student seriously without articulating standards, I think it raises questions," he said.
但是航空公司在冬季假日期间的经营更加困难。2012年,大约有30%的冬季假日航班延误,高于2011年和2010年的航班延误率。你可以通过美国交通运输部的网站查看假日航班的统计数据。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 广东:唤醒“沉睡”的土地
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

罗宾威格尔斯沃思(Robin Wigglesworth)

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

I wonder if the Pelicans are in that position, too. It looks like their highest Brow-era pick will be Buddy Hield. That's not optimal.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 根治天价学区房须平衡教育资源
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

人类在过去50年的平均寿命比人类存在的20万年中的平均寿命要长的多。目前,人类的平均寿命是70岁,1950年的平均寿命是47岁,两者存在很大的差异。
差不多人人都知道谷歌的分析工具Google Analytics,但是你是否用过谷歌的网站管理员工具(Google Webmaster Tools)?作为一名营销人员,我认为谷歌的网站管理工具是我用过的最重要的免费工具之一。你肯定想让自己公司的名字出现在谷歌搜索结果之中,对吧?那么为什么不听听谷歌网站管理员工具教给你的诀窍呢?
The untitled movie revolves around two intersecting love triangles, obsession and betrayal, set against the music scene. It stars Christian Bale, Cate Blanchett, Michael Fassbender, Ryan Gosling, Rooney Mara and Natalie Portman.
《橘色》,导演:肖恩·贝克(Sean Baker)。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 家居市场逢淡季 商家联盟求突破
Review Article

Influenza neuraminidase: A druggable target for natural products

Trium的学员重视与资深和国际高管一同学习的机会。一位学员表示:“它允许我们彼此交流(想法),获得和课程本身一样多的额外知识。”
用户说,语音信息的传输速度很快,可以在微信平台上对话。但和微软(Microsoft Corp.)的Skype等免费语音应用不同的是,在微信上还可以另选时间回复别人发来的语音信息。北京微信用户Robin Wang说,我可以决定什么时候回复,以及回不回复。
Such borrowing is predicated in part on the assumption that by decontextualizing a style you also strip it of any possible negative implications: military, dynastic, what have you. It becomes an aesthetic form that exists on its own terms, as opposed to one that symbolizes all sorts of complicated societal or political convulsions.
Global gold production rose to 3,268.7 tonnes in 2017 from 3,263 tonnes a year earlier, according to the WGC. That was the smallest increase since 2008, when gold mined fell more than 2 per cent during the financial crisis.
Wal-Mart U.S. president and CEO Bill Simon

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

So many are tuning out. Denial. Truth is, bubbles are everywhere. Ready to blow. The evidence is accelerating, with only one obvious conclusion: Max 98% risk at a flashpoint. This 2014 crash is virtually guaranteed. There's but a narrow 2% chance of dodging this bullet.
'With women, he has this sort of patronising carnal attitude with them which is absolutely accurate to the Bond of the books. But then by creating very strong women he is given quite a run for his money and his attitudes are challenged.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

答:AZ里面的角色不是我创作的。在最初版本出来之前,我给故事写了大纲。但伊奈帆这个角色最后呈现出来的,其实和我写的不大一样。我和这个角色之间没什么联系,所以说这个人物算是例外吧。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

制造业PMI降至5个月以来的最低水平,是由于受访企业表示,更严格的环保政策限制了业务扩张。这些政策旨在遏制每年冬天笼罩中国大部分地区的有毒烟雾。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

It was unearthed by archaeologists in 2012 and has since been kept at the Yizheng Museum. It is not shown to the public.
从10年和20年的时间跨度来看,地域和资产类别的多元化已经证明对投资回报和风险管理有益。不幸的是,在12个月内,不一定能看到此种战略的好处。在如今这个140字微博消息和2分钟短视频盛行的时代,投资者不能以长期的表现来判断其投资组合的成败,又有何奇怪?
When reflecting on the year in film, moviegoers often remember strong performances, or they might consider how a movie worked as a narrative, the emotions it evoked, what chances it took.
Mr. Anderson wanted an abundance and a variety of facial hair on the men, with no beard or mustache adorning each actor’s face in quite the same way. It’s a veritable hipster’s row of styles, from pencils to handlebars to a black-and-gray goatee worn by Jeff Goldblum.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Against: It's not yet managing to win top honors from critics' groups.
3. The 2012 Ig Nobel Accoustics Prize
不过,在长达四小时的马拉松般的颁奖典礼中,《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯(Barry Jenkins,文首图中)和塔雷尔?阿尔文?麦克拉尼(Tarell Alvin McCraney,文首图右)获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖,这是美国穆斯林男演员首位获得奥斯卡奖。
居民社区

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

她对“广告狂人狂热症”的定义是“想像《广告狂人》中的人物那样着装”,不过,我想把它的定义改为,大众时装公司认为所有的消费者都想穿成《广告狂人》中的人物那样。该剧的视觉冲击力非常强大,以病毒级传播,仿佛重组了设计师们的创意DNA。
斗转星移关我何事?我的癖好才最重要。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 集体用地建房出租一举多得
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Going into the debate at Lynn University in Boca Raton, Florida, Obama had an inbuilt advantage on foreign policy and security. As president, with access to daily briefings by intelligence analysts, diplomats and generals, he is better briefed and it showed as he dominated Romney in the first half of the debate.
4. OPEC’s Next Move.OPEC deserves a lot of credit (or blame) for the remarkable downturn in oil prices last year.While many pundits have declared OPEC irrelevant after their decision to leave output unchanged, the mere fact that oil prices crashed after the cartel’s November meeting demonstrates just how influential they are over price swings. For now OPEC – or, more accurately, Saudi Arabia – has stood firm in its insistence not to cut production quotas. Whether that remains true through 2015 is up in the air.
Funded partly by firms and companies, the charity places top graduates in schools serving low-income communities for at least two years, knowing full well that many of them will leave the profession at the end of this period.
可以想象,2016年油价将从当前不到40美元的水平上反弹。沙特或许会尝试减产,伊拉克可能会爆发更多冲突,恐怖主义分子可能会攻击一些重要目标,比如沙特拉斯坦努拉和阿巴奇克的石油终端。一切皆有可能,有些事情发生的可能性更大一些。但问题在于,油价反弹的幅度将有多大?
我的同事Sylvia Guinan让我意识到,热爱足球的丈夫应该告诉他的妻子在2014世界杯期间需要注意的一些事情。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The pipelines were building in spite of poor performance for this year’s high-profile deal from Snap, the owner of Snapchat, in the US and investor concerns that a strengthening euro may curtail the earnings recovery in Europe.
为回应这起事件,借贷宝12月1日在其新浪微博上发表了一份公告,强调用裸照作抵押贷款是用户之间的私人交易,该公司无法加以管理。
The 60-episode TV drama was adapted from a novel Legend of Princess Pearl published in 2007. It focuses on the protagonist Shen Zhenzhu’s romance with her husband and their efforts to protect the country.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

《佛罗里达乐园》
Beijing targets consumer prices inflation at 3.5 per cent, but weakening growth is keeping prices benign.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

In New York it is illegal for anyone to rent out a room in an apartment in a multifamily building for less than 30 days if a tenant is not present. Yet almost weekly, someone writes to Ask Real Estate seeking advice on how to skirt the rules. What if I swap apartments? What if nothing is in writing?
Czech model Petra Nemcova went for a dress in white, which featured an extremely plunging neckline and thigh-high split. Ensuring that both her lithe legs were highlighted to the max, the stunning blonde made sure all eyes were on her as she sashayed down the red carpet.
单词associate 联想记忆:

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Will the rest of the world cooperate?
Days after her death, Ross’ mother, Alicia Jesquith, told reporters she needed answers for the sudden death of her daughter, described by friends and family as a vibrant, ambitious young girl who lit up the room.
5. 杜克大学福库商学院

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 上市公司炒房背后的隐忧
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

1. You became a LinkedIn superstar overnight。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

3.Porto, Portugal

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

'I have to echo that, You have steel in your eyes when you sing. You are totally focused. The first time I heard this song it was fantastic, well this was a step up,’ Simon shared.
已经60岁的微软老大净资产达到750亿美元,尽管比起2015年缩水了42亿美元,却仍足以傲视群雄。自2014年超越墨西哥首富卡洛斯·斯利姆·埃卢以来,盖茨实现了福布斯富豪榜榜首三连庄。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

In global health, 2016 will be remembered as the year a little known virus made a major impact. It felt strangely familiar, but this time it wasn't Ebola making headlines around the world, it was Zika - a mosquito-borne virus being linked to a huge spike in the number of babies in Brazil born with brain defects.
Eleven James:
换句话说,我们看到的只是气候变化方面的虚假黎明。
In contrast, the nation witnessed a tumbling trend for minivans, whose volume totaled 71,300 units, a 31 percent drop year-on-year.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

另外一件性玩具则显然属于中国皇室。
单词protection 联想记忆:

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

That Teach First was able to overcome such conditioning is testament to the power of a scheme that has become both a rival to UK private sector recruiters and a finishing school for them.
1. Beyoncé “Beyoncé” (Parkwood Entertainment/Columbia) An ambush that landed after last year’s tabulations, Beyoncé's tour de force — a lustrous showcase of soulful dominion, sleek production, sensual abandon and feminist agency, not always in that order — kept its relevance during a long year swollen with distractions. The singing, like the attitude, is phenomenally assured yet full of nuance; the message is complicated but clear. It’s high-wire pop that refuses to pander.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

['ru:m?]

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The World Health Organization this year declared H1N1 a global epidemic. Fortunately, it is much less threatening than people previously believed, and newly introduced vaccines seem to have quelled lingering fears.
谅解是赢家永远不会拿走一切。
castle
2.喷气背包

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

8.文盲
那么,当你看到17岁的尼克?达洛伊西奥(Nick D’Aloisio)意气风发地走进伦敦巴尔?布鲁(Bar Boulud)餐厅,与人坚定地握着手,描绘他未来事业蓝图的时候,你应该会惊讶得合不拢嘴了吧。他就像是个来自硅谷的首席执行长(CEO),应对媒体时从容不迫,技巧上可以打97的高分。聊天时,他眼神坚定地注视着你,从诺姆?乔姆斯基(Noam Chomsky)的理论、神经网络科学,到移民心态乃至佛教瑜伽,他一切话题都能自信地畅所欲言。但他又像是个One Direction男孩组合的成员,修长的身材配着嬉皮T恤和修身小西装,头发凌乱地搭在脑门前,一边咬着吉士汉堡,一边发表着让人瞠目结舌的见解。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Talk show host and comedian Ellen DeGeneres will host the Oscars ceremony for a second time.
Indeed, everyone from Jennifer Garner, to January Jones and Kylie Jenner have been photographed as they pick out their most spook-worthy pumpkins in time to send October out with a thrill.
吉尔伯特说:“我们很容易看到,在当下的市场中,领头羊们都处在相当脆弱危险的地位。看看他们在每款新设备上做出创新的速度,我们可以很明显地发现这一点。”

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Insead is top of the 2017 Financial Times global ranking of the best 100 MBA programmes. It is the second year that the multi-campus international business school has taken the number one spot, after claiming it for the first time last year.
对于美联储(Federal Reserve)预计本周宣布的加息已经产生了效应,还是会进一步加大负债企业和经济体所受的压力,投资者意见分歧。
scary puppy like head tilts and glares

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

它还体现在萝塞拉·亚尔迪尼(Rossella Jardini)为莫斯奇诺(Moschino)设计的2009年春夏系列的蝴蝶结和宽松裙子上以及以玛丽·匡特(Mary Quant)为灵感的2013年春季系列中。
The second most sought-after job, according to Zhonggong, was a position offered by the regional earthquake bureau in the Inner Mongolia autonomous region, which had 768 applicants as of Tuesday.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 乐居发布“1+1+7”全新业务战略
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

最近几年,中国赴韩旅游出现了蓬勃发展,这让韩国的零售商高兴不已,不过也激怒了韩国国内的游客,因为他们发现韩国旅游景点被来访游客淹没。
After the success of The Conjuring, Ed Warren and Lorraine Warren are back to kick some ghost butts. Conjuring 2 is based on the Enfield Poltergeist, which is apparently a true event that took place in London in 1977.
The life expectancy of the average human has increased more in the past 50 years than it did in the 200,000 years of human existence. Life expectancy is now 70 years old – which is a big difference from 47 years old in 1950!

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

在这个风云变幻的世界,詹姆斯·邦德俘获了不少铁杆粉丝,是至今为数不多的仍在续拍的电影之一。在人们的意识里,无论发生什么事情,新的007电影依然会拍下去。
我们不会越俎代庖,不会超越区域去做不应是中国做的事情。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Profits at China’s biggest banks shrank in 2015, as the sector weathered a year of central bank rate cuts and saw an end to easy profits after the government lifted the cap on interest rates on deposits.
开发活动也处于白热化。GitHub网站上的贡献者图标显示,2014年11月,对比特币主码的贡献总量处于2012年春季以来的最高值。此外,就被“分叉”的次数而言,比特币在GitHub上90多万储存库中名列第31位,“分叉”基本是指提议或正在对核心代码进行的改动。换言之,对于开发者来说,比特币风头正劲。比特币公司目前公布的空缺职位的数量,也突显了开发者的兴趣。跟踪该趋势的Bitcoin Pulse称,如今,此类空缺职位数高达105个,接近九月137个的历史最高值。
Several car names were among the top 50, from ‘ferrari’ to ‘mercedes.’

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

这使得“教育科技”初创公司(比如硅谷的Coursera和伦敦的FutureLearn)在市场上有了立足点。预计它们在2018年将继续这种模式,或许会与某个实体高等教育机构合并。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

A 9.1-percent drop in the annual average density of fine particulate matter (PM2.5) was seen in 74 major cities.
Supply-side structural reform: Cutting overcapacity, destocking, deleveraging, reducing costs and identifying growth areas

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

英国统计学家不愿纠正RPI服装价格部分的已知错误,每年把巨额资金从学生、新毕业生、纳税人和铁路通勤者重新分配给了与该指数挂钩的英国政府债券持有人、领着与RPI挂钩的退休金的富裕退休金领取人、以及铁路公司。
阿里巴巴旗下品牌淘宝位居第二,品牌价值429亿美元,超过了中国移动、百度和中国工商银行。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

让温馨的祝愿、幸福的思念和友好的祝福,在新年来到你身边,伴你左右。
Common areas include two living rooms, both with walls of glass opening to a patio and an in-ground pool. Ceilings rise as high as 28 feet; doors throughout are Spanish cedar. Among the stainless-steel kitchen appliances are a Fisher & Paykel range and two Sub-Zero refrigerators, as well as steel cabinets and sinks. A breakfast bar separates the kitchen from the dining area, which also opens to the patio and pool.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

'Short Term 12' is one of those small indie features that stays with you in a big way. It's only 96 minutes long, a modest production set in a foster-care facility for troubled teens. Yet Destin Cretton's direction and Brie Larson's performance elevate the film to, well, one of the year's very best. Ms. Larson is almost a sure thing for not getting an Oscar-this year's competition is unusually fierce-but do catch up with her portrayal of Grace, a 20-something supervisor who is far from untroubled in her own life.
事实上,贷款给Seppenwolde的那些机构一个荷兰盾都没损失。他们在几周内就清空了全部的东印度股票,收回了所有贷款。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

测试

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

每个句子后面有5个数字,选择最能反映你的感受的数字。
The show’s sense of humor remains keen without relying on nudity, swearing and sexting. This gives the show a refreshing aura in an age where shows are constantly trying to push the envelope in terms of racy content.
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.
The school’s network was vital in helping me find a job in one of the most prestigious companies worldwide, says one graduate from Rotterdam School of Management. The company was a corporate partner so I basically received the job application in my mailbox.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

两乐设备是青铜做的可以追溯到2000多年前中国的汉朝(公元前206年–公元220)。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

今年发展的主要预期目标是:
In comparison, second-tier cities reported worsening congestion, an increase of 3.7% on average, with Chongqing, Changchun, Jiaxing and Shenyang leading the rate of growth at over 7%.
So with such a strong South American contingent, where will the main challenge come from ? Well, the big guns from Europe is the obvious answer. And where else could you look for a team of Champions than Spain. Having won the last World Cup, sandwiched between two European Championship triumphs, this is a team that not only knows how to play fantastic football, but that knows how to win. So whilst Messi and Ronaldo get all the annual plaudits and player of the year titles, the likes of Xavi and Iniesta go about winning all the major trophies. So will they be as string this year ? Well, worryingly for the rest of the world, yes. Not only are most of the old guard still there but talented youngsters such as Koke and Thiago Alcantara have joined the ranks. Not only that, but they've managed to grab a prolific striker, Diego Costa, from under the noses of the host nation, with the Atletico Madrid forward opting to play for Spain, rather than the nation of his birth.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

The EU’s Americas gambits
新美国基金会(New America Foundation)高级研究员李?德鲁特曼(Lee Drutman)在一份给Vox的分析文章中指出,在阿肯色州、北卡罗莱纳州和田纳西州,移民人口是1990年的三倍以上。围绕这些变化产生的焦虑或许可以解释共和党为什么在这个阶段更关注限制移民问题,还有这些州的白人投票者们何以压倒性地支持特朗普。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

一位毕业生表示:“伦敦商学院拓宽了我的专业视野,开启了国际职业机遇。”他补充称:“在毕业后的3年里,我在美国、加拿大和香港工作过,辗转于公司银行业务、债务资本市场等多个领域。”
年龄:33岁

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: “冰丝带”上午全部“跃出”地面
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

"People should just never walk away and leave their animals," Ms Lewis said. "Everyone has a legal obligation to look after animals in their care."

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Nepal remains a fabulous choice for budget-conscious travelers, whether it's the country's world-famous trekking routes or the wildlife in the southern region. Travel costs per day are as low as $50 on average.
3.3 进一步释放国内需求潜力
5.3-D Printed Ears

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

“Yao represents the new wave of wealth creation by financial investments in China,” said Rupert Hoogewerf, who compiles the annual list.
一个由BuzzFeed News(译者注:类似今日头条的新闻搜集网站)所做的分析揭示了本年度Facebook上流传最广的50条假新闻。他们加起来大约有2150万次的点赞、评论及分享。在这些新闻里,23条和美国政治相关,2条关于女人用她们的阴道作为谋杀用的凶器,还有1条关于一个小丑娃娃其实一直都是个真人。
“The Diary of a Teenage Girl” (Marielle Heller)
最后,今年只有两所学校首次登上开放课程排行榜。上海交通大学安泰经济与管理学院(Antai College of Economics and Management)直接排到第32名,而亚利桑那大学(University of Arizona)艾勒管理学院(Eller College of Management)在75所院校中排名第68位。

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 保定每年5000万元专款引进人才
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Getting sector calls right was the least of any investor’s problems this year because, outside of the brilliance of U.S. stock gains, the lights were off around the world.
今年银幕上的发型和化妆各式各样,大胆新颖,从《魔法黑森林》(Into the Woods)中女巫卷曲、蓬乱的蓝色调鬃毛,到《激乐人心》(Get On Up)中詹姆斯·布朗(James Brown)微微发亮、精心塑造的大背头。有时,秃头也能发挥作用,比如《法老与众神》(Exodus: Gods and Kings)中拉美西斯的秃头、重眼影造型。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The London school’s MBA is ranked first in Europe, its EMBA programme, delivered jointly with Columbia Business School in the US, is ranked third and its MiM programme is in the top 10 on its first participation. The MiM ranking was the last missing piece for LBS to come first in Europe.
Plenty of technology companies are angling for a piece of the action, from established players such eBay’s Magento , IBM , and NetSuite to smaller developers including Shopify and Volusion. But relative underdog Bigcommerce is stealing mindshare and market share, fueled by more than $75 million in venture capital, including $40 million from entrepreneur Steve Case’s Revolution Growth firm.
Until a couple of games ago, Stephen Curry really hadn't thought much about making more NBA history.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

12-year-old girl finds ancient Egyptian amulet
2016年,中国电影票房经历了一次令人震惊的调整,从2015年的48%大幅下降到3.7%。

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